(4-tert-Butylphenyl)acetic acid
نویسندگان
چکیده
In the title compound, C(12)H(16)O(2), the plane of the carboxylic acid group is almost perpendicular to the benzene ring [dihedral angle 80.9 (3)°] and the tert-butyl unit is disordered over two sets of sites in a 0.503 (6):0.497 (6) ratio. In the crystal structure, centrosymmetric dimers arise from pairs of O-H⋯O hydrogen bonds involving the carboxylic acid groups.
منابع مشابه
Crystal structure of (tert-butylcarbamoyl)(4-chloro-2-oxo-2H-chromen-3-yl)methyl acetate
In the title compound, C17H18ClNO5, which was synthesized by reacting 4-chloro-3-formyl-coumarin, acetic acid and tert-butyl isocyanide, the acetamido side chain is convoluted with ring-to-side chain C-C-C-C, C-C-C-N and C-C-N-C torsion angles of -123.30 (14), -135.73 (12) and 176.10 (12)°, respectively. In the crystal, N-H⋯O and weak C-H⋯O hydrogen bonds are present, which together with π-π co...
متن کاملSynthesis of imidazol-1-yl-acetic acid hydrochloride: A key intermediate for zoledronic acid
A convenient and practical synthesis of imidazol-1-yl-acetic acid hydrochloride was achieved via N-alkylation of imidazole using tert-butyl chloroacetate followed by a non-aqueous ester cleavage of the resulting imidazol-1-yl-acetic acid tert-butyl ester in the presence of titanium tetrachloride. The synthesized imidazol-1-yl-acetic acid hydrochloride was then utilized to prepare zoledronic acid.
متن کامل{2-[Bis(2,4-di-tert-butylphenoxy)phosphanyloxy-κP]-3,5-di-tert-butylphenyl-κC 1}[(1,2,5,6-η)-cycloocta-1,5-diene]rhodium(I) toluene monosolvate
The reaction of (η(3)-all-yl)[(1,2,5,6-η)-cyclo-octa-1,5-diene]rhodium(I) with tris-(2,4-di-tert-butyl-phen-yl)phosphite in toluene produces the title compound, [Rh(C(42)H(62)O(3)P)(C(8)H(12))]·C(7)H(8), by spontaneous metallation at one of the nonsubstituted phenyl ortho-C atoms of the phosphite mol-ecule. The coordination geometry at the Rh(I) ion is distorted square-planar. The toluene solve...
متن کامل2-(1-Amino-4-tert-butylcyclohexyl)acetic acid (tBu-β3,3-Ac6c) hemihydrate1
The title compound, C12H23NO2·0.5H2O, crystallized with two 2-(1-amino-4-tert-butylcyclohexyl)acetic acid mol-ecules, which are present as zwitterions, and one water mol-ecule in the asymmetric unit. The mol-ecular structure of each zwitterion is stabilized by an intra-molecular six-membered (C 6 ) N-H⋯O hydrogen bond. In the crystal, the two independent zwitterions are linked head-to-head by N...
متن کامل2-(2-Chlorophenyl)-3-(3,4-dimethoxyphenyl)quinoxaline
The title compound, C(22)H(17)ClN(2)O(2), was synthesized by the condensation reaction between 1,2-phenyl-enediamine and 2-chloro-3',4'-dimeth-oxy-benzil in boiling acetic acid. The chloro-phenyl and dimeth-oxy-phenyl rings make dihedral angles of 78.45 (5) and 35.60 (4)°, respectively, with the quinoxaline unit.
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